Undergraduate Chemistry Department:
Medicinal chemistry is an interdisciplinary science, which has seen enormous growth in the past decade. Traditionally accepted as a branch of organic chemistry, the subject has reached a tremendous level of complexity today. It involves many aspects like synthesis, isolation, purification and characterization of anticipated organic compounds that can be used in medicine for the treatment and cure of diseases. On the other hand it establishes a link between chemical structure and biological activity. Medicinal Chemist plays a very crucial role in the design and development of selective, potential, non-toxic, new chemical entities which meet all the desired pharmacokinetic properties.
With the aim to explore and elaborate such fundamentals in a systematic manner undergraduate chemistry department is designed which is comprised of four labs devoted to medicinal chemistry, Analytical chemistry, Organic chemistry, Biochemistry and inorganic pharmaceutical chemistry. Each laboratory is well equipped with state of the art instruments to give hands on experience to the students.
Postgraduate Chemistry Department:
A) SYNTHETIC CHEMISTRY-
The design of “better” molecules is a central aspect in the broader field of medicinal chemistry. Medicinal chemist plays a key role in pharmaceutical research. He is expected to synthesize, purify and analyze novel bioactive compounds. Such organic leads once identified are easy to exploit. He is expected to take all aspects viz., potency, selectivity, toxicity and drug like pharmacokinetic profile of designed New Chemical entities (NCEs). The real test resides with the identification of such lead compound and optimization of positions on the basic skeleton of such leads so as to get bioactive molecules. The advent of research in Medicinal Chemistry has developed to such an extent that we can predict ADMEt taking help of Drug Design Softwares, designed based on the findings of Structure and activity relationships till now. The use of Molecular Modelling techniques on a larger perspective help to reduce manpower efforts, energy, cost, time and chances of failure of drug development at latter stages of drug discovery process. The science now employs the most sophisticated systems with “Drug Design” softwares, all aspects of high-resolution spectroscopy and use of high throughput screening methods. Postgraduate chemistry department has three labs to carry out molecular modeling studies, synthetic and analytical work equipped with sophisticated instruments and softwares to carry out their research work.
B) QUALITY ASSURANCE-
Drugs being a very important component of healthcare, these need special attention especially with respect to quality, efficacy and safety. This has always been a matter of concern from the consumer point of view. The quality control concept basically meant that the quality of the product conformed to the predetermined standards as given in the pharmacopoeia. But the concept was not enough as thereafter the concept GMP emerged in the 1960s in USA. It was however the WHO who played a major role in bringing awareness to the manufacturer of the drug product and national drug regulatory authorities through its certification scheme. The setting of global standard is required by WHO constitution. One of the organization function is that it should “develop, establish and promote international standard with respect to food, pharmaceutical and similar products”.
Responsibility of assuring product quality belongs principally to quality assurance personnel but involves team effort. The manufacturer fulfills his obligation to the consumer by following good manufacturing practices, which ensure that a product consistent high quality is manufactured by him every time. Good manufacturing starts from the time raw material enters the factory and continues into the final dosage form and takes care that it is delivered safely into the hands of consumer.
In the recent past pharmaceutical manufacturing organizations world over have devoted a great deal of effort (resources) to ensure compliance with cGMP guidelines issued by licensing authorities. The Indian pharmaceutical industry in particular has demonstrated remarkably its ability to comply with the stringent requirements of regulatory authorities like the USFDA and UKMCA, etc. Still except for multinational companies and a few other pharmaceutical companies, GMP did not percolate to a large number of medium and small-scale pharmaceutical companies.
In the view of change which is taking place Indian pharmaceutical industry; to stand in the global market, Quality assurance department is set to help the students to learn and understand the concepts of cGMP, GCP, GLP, etc. and implement them successfully to industry.
- Molecular Modeling: Molecular Modeling studies like 2D,3D QSAR , ADMET prediction and docking studies.
- Synthesis and characterization: Synthesis of designed compounds can be carried out using conventional and GREEN CHEMISTRY techniques using Microwave etc.
- Validation of equipments, process.
- Analytical method development and validation
- Formulation development
Molecular Modeling: We can provide services to carry out the Molecular Modeling studies like 2D,3D QSAR , ADMET prediction and docking studies.
Synthesis and characterization: Synthesis of designed compounds can be carried out using conventional and GREEN CHEMISTRY techniques using Microwave etc.
Dr. M C Damle (HOD & Professor)
Dr. S. V. Bhandari [Professor]
Dr. S. V. Gandhi [Professor]
Dr. Mrs. T. S. Chitre [Associate Professor]
Mr. P.B. Deshpande (Assistant Professor)
Mrs. K.D. Aasgaonkar (Assistant Professor)
Mrs. S. M. Patil (Assistant Professor)
Mrs. V.N. Wable (Assistant Professor)
Mr. Shrikant Morkar (Assistant Professor)
Mr. Manohar R. S.(Lab Assistant)
Mr. Chingale G. Y(Lab Assistant)
Mr. Chingale R.Y. (Lab Assistant)
Mr. Chingle R. Y. (Lab Assistant)
Mr. Bandal (Peon)